Even though the championship began three weeks ago, this weekend will be the first time this season that there will be a full fixture list, with six games taking place.
Three teams – Apoel, Apollon and Omonia – will be competing for the first time while a further four teams will be playing their second games.
On Saturday the game that stands out is between Nea Salamina and champions Apoel.
Salamina’s last win over Apoel dates back to 2011 and in the eight games since, they have managed just one draw, conceding 26 goals and scoring just twice.
The Famagusta team brought in no less than 14 players during the summer transfer window and have also recruited young Cypriot coach Liasos Louka to manage the team.
The most notable transfer was that of Gaston Sangoy, the talismanic Argentinian forward who previously played for Apollon. However it is doubtful that Sangoy will start against Apoel as he picked up an injury in his team’s previous outing.
However Kousoulos and Mintikkis who missed the last game are available for selection.
Apoel have their own injury concerns with Efraim, Bertoglio, Milanov and long-term absentee Ioannou all out of Saturday’s visit to the Ammochostos stadium.
This will give the chance to at least one of Apoel’s new signings, Praxitelis Vouros, to start the game in place of right-back Milanov.
Other newcomers challenging for a place in the starting line-up are Hungarian starlet Rolland Salai and Ghayas Zahid, a Norwegian footballer of Pakistani descent.
The other big team from Nicosia, start their campaign against Ethnikos Achnas at the GSP stadium on Sunday.
Expectations at Omonia have shot up since the arrival of the wily Pambos Christodoulou as manager. This is evident from the fact that Omonia fans packed stadiums wherever their team played in the build-up to the new season.
Christodoulou has chopped and changed his team significantly this summer with only six players remaining from last year’s squad and may require a bit of time before his team gels.
Ethnikos Achnas are one of two teams (Olympiacos being the other) who were banned from making any transfers due to financial irregularities.
Despite thumping three past Pafos FC last time out they will need to be at their very best if they are to get a positive result in Nicosia.
The most attractive team of last season, cup holders Apollon, begin their quest for the title against the youthful, yet very competitive Olympiakos at the Makarios stadium.
The Limassol team, strengthened considerably during the summer, with the likes of Nicola Martinez, Liverpool loanee Allan Rodrigues de Souza and former Omonia hitman Andre Skembri.
It should prove a tough day for Olympiakos’ youngsters.
In the other games AEL take on Doxa Katokopias at the Tsirion on Saturday while on Sunday Pafos are up against Alki while Anorthosis entertain Aris at the Antonis Papadopoulos.
The final game will be played on Monday between pointless so far Ermis Aradippou and AEK.
Saturday: Olympiakos vs Apollon (6pm), AEL vs Doxa (7pm), Salamina vs Apoel (8pm)
Sunday: Pafos vs Alki (6pm), Omonia vs Ethnikos & Anorthosis vs Aris (7pm)
Monday: Ermis Aradippou vs AEK (7pm)