New Arsenal signings Pierre-Emerick Aubameyang and Henrikh Mkhitaryan will get an early taste of the north London derby atmosphere when they face Tottenham Hotspur at Wembley on Saturday (2.30pm).
The pair enjoyed comfortable home debuts in last weekend’s 5-1 rout of Everton but their local rivals are sure to provide tougher opposition as the two teams continue their bids for Champions League qualification.
Spurs are fifth in the table, four points ahead of sixth-placed Arsenal, one behind fourth-placed Chelsea and two adrift of third-placed Liverpool with 12 games left.
Arsenal outplayed Tottenham in a 2-0 victory at the Emirates Stadium in November but Spurs have every reason to be confident having soundly beaten second-placed Manchester United and drawn 2-2 at Liverpool in their last two games.
Liverpool travel to St Mary’s on Sunday (6.30pm) to face a Southampton side who ended a 12-match winless run in the league and climbed two points clear of the relegation zone with a 3-2 victory over West Bromwich Albion in their last match.
Chelsea, meanwhile, will welcome bottom club West Brom to Stamford Bridge on Monday (10pm) on the back of losing 3-0 at home to Bournemouth and 4-1 away to Watford.
The results prompted widespread speculation that manager Antonio Conte would be sacked, but it appears that Chelsea’s board are prepared to give the Italian time to arrest the champions’ slump.
Another blip against West Brom, who have won only three times this season and sit four points from safety, would almost certainly put Conte back on the brink of losing his job.
Leaders Manchester City have the chance to bounce back from being held to a 1-1 draw by Burnley when they host eighth-placed Leicester City on Saturday (7.30pm).
Pep Guardiola’s side missed several good chances at Turf Moor and their gap at the top was cut to 13 points following Manchester United’s 2-0 win over Huddersfield Town.
Riyad Mahrez ended a 10-day standoff with Leicester on Friday when he was pictured returning to the club’s training ground.
Puel indicated Mahrez would not be available for Saturday’s game against City, but British media reported that Mahrez was now keen to play against the team who tried to buy him on transfer deadline day.
Manchester United will hope to secure back-to-back wins when they visit another relegation-threatened team, Newcastle United, on Sunday (4.15pm).
The Magpies are 16th, one point above the relegation zone, and have not won in four league matches.