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Decision on Ebola mass vaccination in August at earliest – WHO

File photo: Health worker injects a woman with an Ebola vaccine during a trial in Monrovia

By Stephanie Nebehay

An independent advisory body will decide in August at the earliest on whether to recommend widespread introduction of an Ebola vaccine, depending on results of clinical trials and the epidemic’s course, the World Health Organization said on Friday.

All three worst-hit countries in West Africa – Guinea, Liberia and Sierra Leone – aim to conduct phase III final-stage clinical trials of experimental vaccines.

Liberia is already testing both the GlaxoSmithKline and Merck-NewLink vaccines, while Sierra Leone and Guinea are due to announce plans soon.

Thousands of health care workers and others exposed to the deadly virus have volunteered to take part in the trials, but the question of mass vaccination of wider populations is open.

WHO spokesman Christian Lindmeier, reporting on a three-day meeting of experts, told a news briefing: “Vaccine introduction is by no means a given and will depend on the results of clinical trials and recommendations from WHO’s Strategy Advisory Group of Experts (SAGE) on vaccines and immunisation.

“The earliest that the SAGE is expected to make recommendation on a wide-scale introduction is August. Decisions on whether or not to introduce the vaccine will be made by the respective ministries of health of countries.”

There are “many unknowns”, Lindmeier said. “It will depend on outcomes of clinical trials, evolution of the epidemic etc.”

A steep fall in Ebola cases recorded in Liberia will make it hard to prove whether experimental vaccines work in a major clinical trial, meaning some testing may have to be moved to Sierra Leone, the head of the US National Institutes of Health (NIH) said in late January.

WHO spokeswoman Margaret Harris said: “We know the vaccines are safe, we know they produce a good immunogenic response in humans, but we don’t know if they are effective when you actually have disease in community.”

Guinea, Liberia and Sierra Leone reported 99 new confirmed Ebola cases in the week to Feb. 22, down from 128 the previous week, the WHO said on Wednesday.

In all, more than 23,500 cases have been reported in the three West African countries, with more than 9,500 deaths, since the world’s worst outbreak of Ebola began in December 2013.



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