Three people were killed and one was wounded when gunmen opened fire on a group of people on a street near the University of Maryland, Baltimore, police said on Wednesday.
Two gunmen emerged from two separate light-colored vans and began shooting people just before 11 pm on Tuesday (0300 GMT Wednesday), campus police said in a statement.
A male was pronounced dead at the scene and a male and a female died while receiving medical treatment, the police said. The fourth victim, a woman, was hospitalised.
Police urged people in the area to exercise caution while the gunmen were sought.
The Baltimore Sun reported that shots were fired into a vehicle traveling on the same block five days ago.