Apoel can clinch a sixth straight Cyprus football championship with victory over Anorthosis at the GSP stadium in Nicosia on Saturday evening.
The champions go into the final round of the season with a one-point advantage over Apollon, after trailing the Limassol side for most of the playoffs.
Apollon face struggling Omonia in Nicosia 24 hours later, hoping to still have a chance of winning the championship.
If Apoel draw or lose to Anorthosis, Apollon will be able to swoop in and take advantage in what has been a thrilling title race.
Apoel v Anorthosis 7pm
Olympiakos v Ermis 5pm
Omonia v Apollon 7pm
AEK v AEL 7pm
Doxa v Pafos FC 5pm
Nea Salamina v Alki 5pm