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Chinese inactivated vaccines effective against COVID-19 in phase-3 human trials

(eyesonsci) china beijing covid 19 inactivated vaccine clinical trials (cn)
A sample of the COVID-19 inactivated vaccine is seen at a vaccine production plant of China National Pharmaceutical Group (Sinopharm) in Beijing, capital of China, April 10, 2020. China has approved two COVID-19 inactivated vaccine candidates for clinical trials, according to the State Council joint prevention and control mechanism against the coronavirus Tuesday. The two vaccine candidates were developed by Wuhan Institute of Biological Products under the China National Pharmaceutical Group (Sinopharm), and Sinovac Research and Development Co., Ltd, a company based in Beijing. Clinical trials of the two vaccines have started. (Xinhua/Zhang Yuwei)

Two inactivated vaccines developed by the Chinese pharmaceutical giant Sinopharm have shown to be safe and effective against COVID-19 in phase-3 human trials, according to a study published this week in The Journal of the American Medical Association.

The randomized, double-blind and placebo-controlled trials were designed by the Wuhan Institute of Biological Products Co, Ltd, and the Beijing Institute of Biological Products Co, Ltd, both of which belong to the China National Biotec Group(CNBG), affiliated with Sinopharm.

It is the world’s first published phase-3 study results of inactivated COVID-19 vaccines, the CNBG said in a statement on Thursday.

According to the study, more than 40,000 people overseas aged 18 and above were enrolled in the trials. The vaccination procedure included two shots with an interval of 21 days.

The virus strains in the study were isolated from two patients in Wuhan’s designated coronavirus-treating Jinyintan Hospital and separately used to develop the two inactivated vaccines.

Fourteen days after inoculation, all vaccine receivers produced high titers of antibodies, and the seroconversion rate of neutralizing antibodies was higher than 99 percent in both vaccine groups, indicating strong immune responses induced by the two vaccines, the study said.

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