Match-by-match facts and statistics ahead of the next round of Premier League fixtures from Sept. 16-18 (all times GMT):

Saturday, Sept. 16

Wolverhampton Wanderers v Liverpool (1130)

* Liverpool, undefeated in their last 15 league matches, have had a player red-carded in back-to-back league games for the first time since March and April 2015.

* Liverpool’s new midfield signing Dominik Szoboszlai scored his first goal for the Merseyside giants in their 3-0 win over Aston Villa before the international break, with vice-captain Trent Alexander-Arnold securing his first assist of the season in the same match at Anfield.

* Wolves have lost 14 of their 18 league matches against Liverpool, with two matches ending in draws.

West Ham United v Manchester City (1400)

* Pep Guardiola will be back on the touchline against David Moyes’ West Ham, who are fourth in the standings and two points behind leaders City, after missing two games following a back surgery.

* Midfielder James Ward-Prowse (one goal, three assists) is the first West Ham player to either score or assist a goal in his first three league appearances.

* This is West Ham’s joint-highest points tally after their opening four games of a league season, having also earned 10 points in 1999-2000.

Tottenham Hotspur v Sheffield United (1400)

* New Spurs captain Son Heung-min scored his fourth league hat-trick in the north London-based club’s last match against promoted Burnley.

* Second-placed Spurs, with the help of new manager Ange Postecoglou, can make their best start to a league season since 1965 by beating Sheffield United at home.

* This is the first time in the English top-flight that as many as four teams, namely Everton, promoted Sheffield United, Luton Town and Burnley, have lost their opening three games to a campaign.

Manchester United v Brighton & Hove Albion (1400)

* Midfielder Sofyan Amrabat and defender Sergio Reguilon will be among those hoping to make their debut for United at Old Trafford, while 20-year-old forward Rasmus Hojlund is in contention to start after making a cameo at Arsenal earlier this month.

* Uruguayan winger Facundo Pellistri could also be given a chance by United manager Erik ten Hag in the absence of Antony, who will not immediately return to United as the Brazilian addresses assault allegations against him.

* Brighton’s 18-year-old striker Evan Ferguson, who scored his first league hat-trick against Newcastle United earlier this month, is an injury doubt.

Fulham v Luton Town (1400)

* This marks the first league meeting between Fulham and promoted Luton since the 1959-60 campaign.

* Luton could become just the second team to suffer four consecutive losses in their debut top-flight season, after Swindon Town in 1993-94.

* Fulham have dominated at home against promoted sides in the last eight matches (W3 D4), suffering just one loss by Leeds United in March 2021.

Aston Villa v Crystal Palace (1400)

* Villa lost their winning momentum before the international break when they suffered a 3-0 defeat by Liverpool, having recovered from a heavy opening-day loss at Newcastle.

* Villa could get a boost with the return of Alex Moreno following the defender’s injury last season.

* Palace just have two wins in 16 league matches at Villa Park.

Newcastle United v Brentford (1630)

* Newcastle’s new signing Sandro Tonali is an injury doubt after the former AC Milan midfielder missed Italy’s Euro 2024 qualifier against Ukraine.

* Eddie Howe’s Newcastle, who qualified for the Champions League for the first time in 20 years, have lost three of their first four league matches this season. They only lost five games last season.

* Thomas Frank’s Brentford have only been beaten once in their last 11 league matches (W6, D4), a 1-0 defeat by Liverpool in May.

Sunday, Sept. 17

Bournemouth v Chelsea (1300)

* Chelsea’s 115 million pounds record-signing Moises Caicedo is the second player to give away a penalty on his top-flight debut for the west London-based side. The Ecuadorian midfielder did so in his side’s 3-1 loss at West Ham last month.

* Chelsea have two wins from their last 16 league games, including an away victory at Bournemouth.

* New Chelsea manager Mauricio Pochettino is winless in 13 away games in the league, a run that stretches back to Feb. 2019 with his former club Spurs.

Everton v Arsenal (1530)

* Arsenal will look to carry the momentum following a 3-1 home win over league rivals Manchester United.

* Abdoulaye Doucoure scored Everton’s first goal of the campaign when the Mali forward netted the opener against Sheffield United.

* Striker Dominic Calvert-Lewin could make a return for Everton after sustaining a facial injury in last month’s 4-0 defeat by Villa, providing a boost to manager Sean Dyche, who will hope to avoid another relegation battle as his side languishes in 18th place.

Monday, Sept. 18

Nottingham Forest v Burnley (1845)

* Forest, who signed as many as seven players on the transfer deadline day, will miss the services of promising Wales striker Brennan Johnson, who moved to Spurs earlier this month.

* Steve Cooper will, however, rely on new signing Anthony Elanga, who joined from United and has already scored a goal and claimed an assist for Forest.

* Burnley manager Vincent Kompany will look to organise his defence after the promoted side conceded as many as 11 goals in their first three matches.